Antipsychotic medications have a long history of being used in the treatment of depression. The older antipsychotic medications quickly fell out of favor due to side effects like movement difficulties and the potentially permanent side effect of tardive dyskinesia.
Newer antipsychotic medications became available that lessened the movement difficulties, but some of these medications increased metabolic risks through increasing weight, blood sugar, and lipids.
Finally, some antipsychotic medications were shown to help and depression and even became FDA approved for this use.
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